Fundamental Fault in Hypertension by M.P. Sambhi (English) Paperback Book

Description: Fundamental Fault in Hypertension by M.P. Sambhi The fundamental fault in hypertension is unknown. Calling it a fundamental fault, indeed, tacitly begs the question: Is there one fundamental fault, or are there several that are interlinked or interdependent? A simple yes or no answer cannot be offered. This volume is not designed to survey the up-to-date recent advances in research on hypertension, nor intended to provide provisional anÂ swers to the so many unknowns in this topic. It is, in fact, an attempt to articulate questions that are worth asking, given the license of an unhibited, albeit disciÂ plined, inquiry. The range of expression varies from dogmatic opinion to a declared speculation. Is the primary abnormality an excessive sodium and reduced potassium intake over generations? Or is it hormonal excess, deficiency, imbalance or altered synthesis of abnormal forms? Does the nervous system playa role of active initiation or only of passive maintenance in the genesis of hypertension? Is the heart only a pump acting in concert with the happenings to the vasculature trying to provide adequate flow in the face of vasconstriction induced by neural or humoral factors, or does it sometimes become the culprit by pumping blood flow in excess of demand and thus initiating hypertrophic changes in blood vessels, or by assuming the role of an endocrine organ and being the source of a hormone with influence on cellular transport of sodium and on vasomotor tone? Is an elusive and mysterious fault in the kidney, the primary basis of all of the abo FORMAT Paperback LANGUAGE English CONDITION Brand New Publisher Description The fundamental fault in hypertension is unknown. Calling it a fundamental fault, indeed, tacitly begs the question: Is there one fundamental fault, or are there several that are interlinked or interdependent? A simple yes or no answer cannot be offered. This volume is not designed to survey the up-to-date recent advances in research on hypertension, nor intended to provide provisional an swers to the so many unknowns in this topic. It is, in fact, an attempt to articulate questions that are worth asking, given the license of an unhibited, albeit disci plined, inquiry. The range of expression varies from dogmatic opinion to a declared speculation. Is the primary abnormality an excessive sodium and reduced potassium intake over generations? Or is it hormonal excess, deficiency, imbalance or altered synthesis of abnormal forms? Does the nervous system playa role of active initiation or only of passive maintenance in the genesis of hypertension? Is the heart only a pump acting in concert with the happenings to the vasculature trying to provide adequate flow in the face of vasconstriction induced by neural or humoral factors, or does it sometimes become the culprit by pumping blood flow in excess of demand and thus initiating hypertrophic changes in blood vessels, or by assuming the role of an endocrine organ and being the source of a hormone with influence on cellular transport of sodium and on vasomotor tone? Is an elusive and mysterious fault in the kidney, the primary basis of all of the above Table of Contents I. The Preamble.- 1. The long slow road to progress: a lesson in humility.- 2. Sir George Pickerings views on hypertension.- 3. Facts, interpretations and extrapolations on the mechanisms that cause arterial hypertension.- 4. The infinite gain principle for arterial pressure control by the kidney-volume-pressure system.- 5. Hypertension research: a viewpoint.- II. How Important is the Salt Intake?.- 6. Determinants of blood pressure in populations.- III. The Central Role of the Kidney.- 7. The mechanism of sodium-dependent low renin hypertension.- 8. Mills disease amongst medical specialists in hypertension.- IV. A Defect in Cell Membrane Permeability.- 9. Cell membrane permeability and hypertension.- 10. Is biomembrane abnormality a pathogenic factor or a genetic marker of hypertensive diseases?.- V. The Antihypertensive Hormones Of the Kidney.- 11. Hypertension induced by JG-like cells grown in tissue culture.- 12. The glandular kallikrein-kinin system in hypertension.- VI. The Role of the Central Nervous System: Mediation or Initiation?.- 13. The mechanism of hypertension — a personal view.- 14. Arterial baroreflexes in human beings.- 15. Possible mechanism of protection from renal hypertension by anteroventral third ventricle (AV3V) lesions: role of renal afferent nerves.- 16. Neuronal systems and their impact on blood pressure regulation.- 17. Brain catecholaminergic mechanisms and hypertension.- 18. Continuous intra-arterial blood pressure recording in human hypertension.- 19. Role of vasopressin in blood pressure regulation through its modulatory effect on baroreceptor reflex.- VII. Altered Hemodynamics: A Cause or a Consequence?.- 20. Controversies in the research on hemodynamic mechanisms in the development of hypertension.- 21. The role of the heart inhypertension.- 22. Structural change in the blood vessel wall: the fundamental self-perpetuating process in primary hypertension.- VIII. How is the Renin System Involved?.- 23. Is there a fault in the renin-angiotensin system in essential hypertension?.- 24. Biological significance of active and inactive renin in hypertensive patients.- 25. The relation of plasma renin substrate to blood pressure in essential hypertension.- 26. On renin substrate and hypertension: a hypothesis. Promotional Springer Book Archives Long Description The fundamental fault in hypertension is unknown. Calling it a fundamental fault, indeed, tacitly begs the question: Is there one fundamental fault, or are there several that are interlinked or interdependent? A simple yes or no answer cannot be offered. This volume is not designed to survey the up-to-date recent advances in research on hypertension, nor intended to provide provisional an Details ISBN9401090068 Publisher Springer ISBN-10 9401090068 ISBN-13 9789401090063 Format Paperback Imprint Springer Place of Publication Dordrecht Country of Publication Netherlands DEWEY 616.132 Short Title FUNDAMENTAL FAULT IN HYPERTENS Language English Media Book Series Number 36 Illustrations 29 Illustrations, black and white; XII, 346 p. 29 illus. DOI 10.1007/978-94-009-5678-0 Edited by M.P. Sambhi Author M.P. Sambhi Pages 346 Edition Description Softcover reprint of the original 1st ed. 1984 Series Developments in Cardiovascular Medicine Year 2014 Publication Date 2014-08-23 Alternative 9780898386387 Audience Professional & Vocational We've got this At The Nile, if you're looking for it, we've got it. With fast shipping, low prices, friendly service and well over a million items - you're bound to find what you want, at a price you'll love! TheNile_Item_ID:96350717;

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